PCOS

"Conclusion: There was low to moderate certainty of evidence that LC improves Body Mass Index (BMI) and serum LDL, TG, and total cholesterol levels in women with PCOS." Mohd Shukri, Mohd Falihin et al. “Effects of L-carnitine supplementation for women with polycystic ovary syndrome: a systematic review and meta-analysis.” PeerJ vol. 10 e13992. 16 Sep. 2022, doi:10.7717/peerj.13992 (edited)

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Topical L-carnitine for sebum reduction

"Topically applied L-carnitine is bioavailable and leads to a significant sebum reduction in vivo. In conclusion, L-carnitine represents a valuable compound, produced naturally within the body, for the topical treatment of oily skin in humans. " Peirano, R. I., Hamann, T., Düsing, H. J., Akhiani, M., Koop, U., Schmidt-Rose, T., & Wenck, H. (2012). Topically applied L-carnitine effectively reduces sebum secretion in human skin. Journal of cosmetic dermatology, 11(1), 30–36. https://doi.org/10.1111/j.1473-2165.2011.00597.x

Topical licochalcone A, l-carnitine and 1,2-decanediol

"active formulation group showed at the end of the study a reduction in the mean total lesions count and papular lesions, significant reduction in the pustules (P < 0.05) and sebum levels (P < 0.01), marked reduction in P. acnes and improvement of DLQI" Angelova‐Fischer, I., et al. "A double‐blind, randomized, vehicle‐controlled efficacy assessment study of a skin care formulation for improvement of mild to moderately severe acne." Journal of the European Academy of Dermatology and Venereology 27 (2013): 6-11. (edited)

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Carnitine for isotretinoin side effects

"Iso therapy decreases car blood levels in patients with CA. L-car supplementation might treat liver and muscular side effects of the drug. These hopeful preliminary results need further investigation. " Georgala, S., Schulpis, K. H., Georgala, C., & Michas, T. (1999). L-carnitine supplementation in patients with cystic acne on isotretinoin therapy. Journal of the European Academy of Dermatology and Venereology : JEADV, 13(3), 205–209.

10:28 PM

Diabetes

"L-carnitine plays a potential role as adjunctive therapy in diabetes. Additional research is necessary for patients with higher baseline HbA1c and type 1 diabetes." Ko, Jennifer, et al. "The glycemic, cholesterol, and weight effects of L-carnitine in diabetes: A systematic review and meta-analysis of randomized controlled trials." Diabetes Epidemiology and Management 10 (2023): 100122.